Michaelis-Menten kinetics: explicit dependence of substrate concentration on reaction time

One hundred years of Michaelis–Menten kinetics

0.1016/j.pisc.2014 he Author. Publish mons.org/licenses t of an special issu etics”. Copyright thor. [email protected] Abstract The year 2013 marked the centenary of the paper of Leonor Michaelis and Maud Menten (Michaelis and Menten, 1913), and the 110th anniversary of the doctoral thesis of Victor Henri (Henri, 1903). These publications have had an enormous influence on the progress of biochem...

Analytical Expression Pertaining to Concentration of Substrate and Effectiveness Factor for Immobilized Enzymes with Reversible Michaelis Menten Kinetics

On the Dynamics of the Irreversible Michaelis-menten Reaction Mechanism

The mass action kinetic model of the irreversible Michael&Menten reaction mechanism is mathematically intractable: an explicit analytical solution cannot be obtained. This difficulty is overcome by applying simplifying kinetic assumptions but a full understanding of their dynamic implications and applicability is not readily available. This paper shows how simple modal analysis can provide both...

Analytical Expression Pertaining to Concentration of Substrate and Effectiveness Factor for Immobilized Enzymes with Reversible Michaelis Menten Kinetics

A lung retention model based on Michaelis-Menten-like kinetics.

A Michaelis-Menten (MM)-like kinetic model for pulmonary clearance and retention of insoluble dusts was developed and validated by comparing our predictions with experimental data from F344 rats. Published data from inhalation studies involving accumulation and elimination of photocopy test toner, antimony trioxide, carbon black, and diesel exhaust particles were investigated. Numerical integra...